Multiple Functions of Caveolin-1

Multiple functions of caveolin-1.

Versatile Functions of Caveolin-1 in Aging-related Diseases

Caveolin-1 (Cav-1) is a trans-membrane protein that is a major component of the caveolae structure on the plasma membrane. Cav-1 is involved in the regulation of various cellular processes, including cell growth, differentiation, endocytosis, and in particular it has been implied in cellular senescence. Here we review current knowledge about Cav-1 in cellular signaling and discuss the role of C...

Multiple Domains in Caveolin-1 Control Its Intracellular Traffic

Caveolin-1 is an integral membrane protein of caveolae that is thought to play an important role in both the traffic of cholesterol to caveolae and modulating the activity of multiple signaling molecules at this site. The molecule is synthesized in the endoplasmic reticulum, transported to the cell surface, and undergoes a poorly understood recycling itinerary. We have used mutagenesis to deter...

Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma.

OBJECTIVE To study the expression status of caveolin-1, caveolin-2 and caveolin-3 in the epithelial and stromal compartments of conventional papillary thyroid carcinoma (PTC), diffuse sclerosing variant of papillary carcinoma (DSVPC) and anaplastic carcinoma (AC). METHODS Tissue microarrays were constructed from 70 PTC, 41 DSVPC and 12 AC, and immunohistochemical stains were performed with ca...

Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A.

Numerous components of the cAMP-based signaling cascade, namely G-proteins and G- protein coupled receptors, adenylyl cyclase, and protein kinase A (PKA) have been localized to caveolae and shown to be regulated by the caveolar marker proteins, the caveolins. In order to gain mechanistic insights into these processes in vivo, we have assessed the functional interaction of caveolin-1 (Cav-1) wit...